The U.S. has imposed sanctions on three nephews of Venezuelan President Nicolás Maduro and half a dozen shipping vessels accused of transporting Venezuelan oil.

President Trump on Thursday announced new sanctions on the family members of Venezuelan strong-man Nicolas Maduro and Venezuelan businesses, a day after the U.S. seized a Venezuelan oil tanker in an escalation of the administration’s pressure campaign on the country.

Maduro has survived predictions and ridicule, but along the way, Venezuela lost millions of inhabitants, 72% of its economy, democratic legitimacy in the eyes of much of the world, and many of its most important international allies.

Estados Unidos impuso el jueves sanciones a tres sobrinos del presidente venezolano Nicolás Maduro, entre otros, mientras el presidente Donald Trump

Now, President Donald Trump wants Venezuelan President Nicolas Maduro out of power. Maduro’s “days are numbered,” Trump told Politico in an interview released on Dec. 9. His Administration considers Maduro the head of a government-sponsored cocaine smuggling syndicate.

When asked if he could rule out a ground invasion of Venezuela, Trump answered: “I don’t want to rule in or out.”

Machado left Venezuela at a critical point in the country’s protracted crisis, with the Trump administration carrying out deadly military operations in the Caribbean and threatening repeatedly to strike Venezuelan soil. The White House has said the operations, which have killed more than 80 people, are meant to stop the flow of drugs into the U.S.