The Arizona Cardinals were destroyed by the Seahawks last week but they have a chance to get back on track in Week 11, with the 49ers coming to town.

The Arizona Cardinals are back in action in Week 11, facing the San Francisco 49ers for the second time this season. The 6-4 49ers and 3-6 Cardinals kick off from State Farm Stadium in Glendale, Arizona at 4:05 p.m. ET (2:05 p.m. Arizona time).

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

Look back on our live updates of the 49ers-Cardinals game, which was played at the Cardinals' State Farm Stadium in Glendale, Arizona, on Sunday, Nov. 16. Arizona's Jacoby Brissett passed for more yards than any Cardinal since Kurt Warner, but it didn't ...

The Arizona Cardinals were beaten 41-22 by the San Francisco 49ers on Sunday at State Farm Stadium. A lot of thing went wrong. However, moving the ball offensively wasn't one of the problems. They had a season-high 488 yards of offense. They outgained the 49ers 488 to 281 in yards.

Eddy Piñeiro nears return, adding WR Javon Baker while releasing Matt Gay and Adrian Martinez to reshape depth.

Find single game tickets to the San Francisco 49ers vs. Arizona Cardinals NFL Week 11 matchup on Sunday, November 16, 2025 at State Farm Stadium.

Brock Purdy's return went as well as the San Francisco 49ers could have hoped, as they routed the Arizona Cardinals on Sunday.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

How Week 14 games impact San Francisco's NFC seeding, postseason path, and key rooting interests in a tight playoff race.