Nature

Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis

RA (JBZ-0789) and GR (JBZ-1028) were obtained from Nanjing Jin Yibai Biological Technology Co., Ltd (Nanjing, China). Cel (HY-14398) was from MedChemExpress (New Jersey, USA). InvivoMAb anti-mouse ...
Nature

Ecto-5ʹ-nucleotidase/CD73 reduces COX-2 expression in activated macrophages

Extracellular ATP (eATP) is a significant contributor of inflammation through enhanced expression of cyclooxygenase 2 (COX-2). In this study, we explored whether overexpression of ectonucleotidases ...
ascopubs.org

A phase II study with antioxidants, pharmaco-nutritional support, progestagen and anti-COX-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia (CACS ...

Tolerability of dronabinol alone, ondansetron alone and the combination of dronabinol plus ondansetron in delayed chemotherapy-induced nausea and vomiting No significant financial relationships to ...
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...