This Simple Drug Combo Turns THC Into a Potential Alzheimer’s Therapy

New research suggests THC’s cognitive drawbacks may be mitigated when combined with a targeted anti-inflammatory drug. Cannabis research has highlighted a scientific paradox. Its best-known ...
Nature

Anti-Inflammatory Drugs and Cyclooxygenase Inhibitors

Anti-inflammatory drugs have long served as a cornerstone in the treatment of conditions marked by inflammation, pain, and fever. At the heart of many of these therapeutic agents lies the inhibition ...
Medscape

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity

Aspirin was introduced into clinical medicine in 1899 and its anti-inflammatory, analgesic and antipyretic properties were accompanied by the onset of gastrointestinal and renal toxicity. Over the ...
Medscape

Mouse study suggests mechanism behind COX-2-inhibitor cardiovascular risk

Farmingham, CT - A new mouse study published this week provides some insight into understanding why rofecoxib (Vioxx, Merck) and the other cyclooxygenase (COX)-2 inhibitors increase the risk of ...
BioWorld

COX-2 inhibitor AAT-076 ameliorates neuropathic pain

AAT-076 was tested in the preclinical setting for its analgesic potential in COX-1 and COX-2 assays, as well as in in vivo rat models of air pouch inflammation, adjuvant-induced arthritis and ...
The Scientist

Beyond Inflammation: Blocking COX-2 May Provide Therapy for Multiple Diseases

UPSTREAM, DOWNSTREAM: Biochemical activity upstream of cyclooxygenase is better understood than reactions downstream of the enzyme. Cancer, Alzheimer's disease, and stroke represent disparate ...
The Scientist

COX-2 and renal function

NEW YORK, July 18 (Praxis Press) A new class of nonsteroidal anti-inflammatory drugs selectively inhibits cyclooxygenase (COX)-2 and may produce fewer adverse effects than nonselective inhibitors.