Obesity is widely known for increasing the risk of diabetes and cardiovascular disease, but its damaging effects on the skeleton are often overlooked. Excess body fat can disrupt bone metabolism, ...

On the top, (a) Chemical structure of TPZP. On the bottom, (b) Schematic diagram of combined therapy. Art by Michael Rothman. Art by Zhaohui Tang. Hypoxia-activated prodrugs (HAPs) have the potential ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

An implantable zinc magnesium battery generates hydrogen and removes oxygen inside tumors, triggering a hypoxia-activated drug and achieving strong, localized tumor suppression in mice. (Nanowerk ...

The development of various hypoxia-activated prodrugs (HAPs) has made considerable advances in the last few decades; however, cancer therapy using HAPs is still hindered by problems such as poor ...

A self-charging implantable battery that sucks oxygen away from tumors makes some masses more vulnerable to destruction, according to a study published March 31 in Science Advances. When used in ...

BioWorld - Tuesday, April 29, 2025 Breaking News: 100 days of uncertainty See today's BioWorld Science Home » Hypoxia-activated nitric oxide donor disclosed To read the full story, subscribe or sign ...

Oxford University Innovations Ltd. has synthesized hypoxia-activated proteolysis targeting chimeras (hypoxia-activated PROTACs; HAP-TAC) comprising a hypoxia-activated moiety modified E3 ubiquitin ...