DNA replication is one of the most basic processes ... One of these original strands is called the leading strand, whereas the other is called the lagging strand. The leading strand is synthesized ...

In DNA replication, the "leading" strand forges ahead, adding letters as it goes, while the "lagging" strand follows behind, connecting the double helix in fits and starts. Biologists widely ...

On their own, however, polymerases aren't good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand, and ...

One moves continuously to produce the new daughter DNA molecule on the leading strand, whereas the other produces a long series of short Okazaki DNA fragments on the lagging strand. Both ...

DNA is a complex molecule that consists of two strands coiled around each other to form a double helix structure. Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding ...

Additionally, PARPi resistance does occur, complicating treatment and leading to recurrent cancer. "The conventional thinking has been that single-stranded DNA breaks from PARPi ultimately ...