The Bills have reigned over the AFC East for five straight seasons and are off to an excellent start towards a sixth in 2025. Both teams are coming off double-digit victories in Week 4, and the Patriots hope the momentum from their 42-13 beatdown of the Carolina Panthers will carry into tonight's divisional clash.

The UNLV Runnin’ Rebels take on the Wyoming Cowboys slight favorites on the road with Week 6 of the college football season wrapping up.