Many pharmaceuticals need to be a certain shape to fit into the binding pocket of the enzyme they target. Synthesizing molecules with the desired chirality requires controlled addition of functional ...

THE reaction between substituted malonic esters and acid chlorides has been investigated on a number of occasions in the past 1, and has been found to give the corresponding acylmalonic esters in high ...

Diethylmalonate, often abbreviated as DEM, is a colorless, sweet-smelling ester used extensively in organic synthesis. It's a key intermediate in the malonic ester synthesis, a process for creating ...