We identified an miRNA gene expression signature of sensitivity to the EGFR inhibitor, erlotinib, in an NSCLC cell line model system. We hypothesised that members of the signature mediate both ...

Gene expression in cells and tissues of every ... its biological role is proving more and more important. Analysis of miRNA expression may provide valuable information, as dysregulation of its ...

MicroRNAs (miRNAs) represent an extensive class of small endogenous RNAs which regulate gene expression at the post ... encode dozens to hundreds of miRNA genes which play important roles in ...

More information: Kasey S. Love et al, Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells, Cell Systems (2025). DOI: 10. ...

But a study published November 9 in ACS Central Science finds that microRNAs (miRNAs) can also amplify gene expression. “It changes the landscape of microRNA,” Lara Mahal, a chemist at the University ...

[4] This review is centered on PC biomarker development accomplished through microarray-based mRNA and miRNA gene expression profiling.

Using results of gene-expression microarray analysis, we found that expression levels of the microRNA-181 family were inversely correlated with expression levels of predicted target genes encoding ...

Indeed, microRNA-based therapy is attracting major ... to help cancer progression and metastasis by influencing gene expression in neighboring cells. Fluid samples collected from patients with ...

Human microRNA inhibits expression of pathogenic gene underlying facioscapulohumeral muscular dystrophy Dec 14, 2021 Preclinical studies test novel gene therapy for treating IgA nephropathy ...