An insertion mutation occurs when an extra nucleotide is added to the DNA strand during replication. This can happen when the replicating strand "slips," or wrinkles, which allows the extra ...

This DNA has suffered a mutation, either through mis-copying (when its parent cell divided), or through the damaging effects of exposure to radiation or a chemical carcinogen.

Just like the mechanical components in cars or computers, the molecules inside a cell can sometimes malfunction. When this happens during DNA replication, the result is an unpredictable change in ...

PRISM’s genome is engineered to include a repeat sequence with a frameshift mutation. Once inside a cell, the host’s DNA replication machinery reverts the frameshift while converting the single-strand ...

They constantly untangle knots in the DNA strand and create new chemical bonds when a strand ... In the paper, the team lists ...

Fanconi anemia cells cannot resolve the double-strand breaks that conventional CRISPR-Cas9 gene editing creates in the target DNA, which prevents researchers from effectively correcting ...

and double-strand breaks. DNA repair is essential for preventing the accumulation of mutations that could lead to genetic disorders or cancer. Genetic engineering involves the manipulation of an ...

Using a point-mutation strategy ... More information: Xinzhe Tang et al, In vitro reconstitution of meiotic DNA double-strand ...

In general, mutations occur less than once per billion ... The first is the primer, a short single-stranded piece of DNA that binds to a single strand: As and Ts on the primer bind with Ts and ...

DNA polymerase enzymes use the existing DNA strand as a template and add the complementary nucleotides, including thymine, to the growing new strand. Mutations involving thymine can occur during DNA ...

The complex adopts a more compact structure when bound to double-stranded DNA (dsDNA), with the target ... Researchers demonstrated that mutations in key residues of the HNH domain, particularly ...