A team of researchers has used advanced DNA sequencing to develop the most comprehensive atlas yet of genetic change through ...

Using a point-mutation strategy ... More information: Xinzhe Tang et al, In vitro reconstitution of meiotic DNA double-strand ...

PRISM’s genome is engineered to include a repeat sequence with a frameshift mutation. Once inside a cell, the host’s DNA replication machinery reverts the frameshift while converting the single-strand ...

The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the ...

Catching cancer early using a blood test—called a “liquid biopsy”—has long been a goal of cancer research. Such tests would ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to severe conditions. Expression of mtDNA is a prerequisite for ATP production ...

Researchers have developed a light-induced DNA detection method that enables rapid, PCR-free genetic analysis. Their technique offers ultra-sensitive mutation detection in just five minutes, reducing ...

DNA polymerase enzymes use the existing DNA strand as a template and add the complementary nucleotides, including thymine, to the growing new strand. Mutations involving thymine can occur during DNA ...

A new study from Weill Cornell Medicine provides insights into how cells maintain the tiny end caps of chromosomes as they ...

Whether it’s a single-cell organism or a multi-cell being, any living creature can go through mutations that will ... a gene from a plant, and that DNA influx completely changed it in the ...

In general, mutations occur less than once per billion ... The first is the primer, a short single-stranded piece of DNA that binds to a single strand: As and Ts on the primer bind with Ts and ...