Impact on in vitro studies. Nowadays, a large proportion of early discovery assays overexpress the pharmacological target to create a viable in vitro assay. The general assumption is that the ...
The discovery of genetic polymorphisms in drug metabolism has contributed significantly to the understanding of the inter-individual variability in dose-concentration relationships and drug response.
Patients receiving second-line or greater therapy 56.4 weeks 46.7 weeks HR = 0.73; p = 0.024 CrEL = Cremphor EL; HR = Hazard ratio; Nab = Nanoparticle albumin bound. Nanoparticle albumin-bound ...
Phase I Clinical and Pharmacokinetic Study of Flavopiridol Administered as a Daily 1-Hour Infusion in Patients With Advanced Neoplasms PURPOSE: N-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide (E7070) ...
We propose a population pharmacokinetic (PK) model with time-dependent covariates measured with errors. This model is used to model S-oxybutynin's kinetics following an oral administration of Ditropan ...
PURPOSE: N-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide (E7070) is a novel sulfonamide anticancer agent currently in phase II clinical development for the treatment of solid tumors. Four phase I ...
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