The Basel-based company said the investment would go toward high-tech research and development sites and new manufacturing facilities in places including California, Indiana, Massachusetts, and Pennsylvania.

The investment will create more than 12,000 jobs, Roche said — 1,000 with the company, and the remainder to support new U.S. manufacturing capabilities. Swiss pharmaceutical giant Roche on Tuesday said that it would invest $50 billion in the U.

The pharma giant said the investment would create more than 12,000 jobs, as it joins rival Novartis in expanding its footprint in the country amid President Trump’s tariff threats.