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leading to the inactivation of integrin β1 and the suppression of TGFβR/Smad signaling. This cascade of events results in the inhibition of EndMT. The activation of FGFR1 by KLX was confirmed ...
leading to the inactivation of integrin β1 and the suppression of TGFβR/Smad signaling. This cascade of events results in the inhibition of EndMT. The activation of FGFR1 by KLX was confirmed ...
We have shown that dual-SMAD inhibition via small molecule inhibitors of BMP and TGFb/Activin/Nodal signaling is sufficient to trigger neural conversion. Using this technology we are particularly ...