In this article, we propose approximate sample size formulas for establishing equivalence or noninferiority of two treatments in match-pairs design. Using the ratio of two proportions as the ...

Formal sample size calculation can help us think through what patient-based research can and cannot tell us about medicine.

For a desired power of detecting the association between a disease and several potential risk factors in case-control studies, Yang (1978, Biometrika 65, 635-640) and Halperin (1980, Biometrika 67, ...

While this is also dependent the parameters that go into a power calculation, in particular the effect size and sample size of the case group, there is a useful rule of thumb that is worth remembering ...

Course TopicsPower analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required ...