Although the legendary Fountain of Youth that brought Ponce de Leon to Florida in the sixteenth century is probably a myth, four researchers at Harvard Medical School (HMS) may recently have ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the Institute of Science Tokyo reveal that a tandem allosteric effect of ...

Calorie restriction (CR) increases lifespan in organisms that are as diverse as yeast and humans; but, as three papers show, the underlying molecular pathways are complex. A gene that was thought to ...

Low-calorie diets extend lifespan in almost every model tested, but scientists can't yet agree on what controls this phenomenon. The histone deacetylase Sir2 provides a seductive link between gene ...

A handful of genes that control the body's defenses during hard times can also dramatically improve health and prolong life in diverse organisms. Understanding how they work may reveal the keys to ...

Our cells are usually frantically working to sustain life. Part of this work includes dividing, a process that creates more cells to support our growth when we are children or to replace old, worn-out ...

You have full access to this article via your institution. But what does this mean? The authors suggest that, in S. cerevisiae, Sir2 inhibits the initiation of DNA replication at a step early in ...

You might call Candida albicans a shape-shifter: As this fungus grows, it can multiply as single, oval-shaped cells called yeast, or propagate in an elongated form called hypha, consisting of ...

A handful of genes that control the body's defenses during hard times can also dramatically improve health and prolong life in diverse organisms. Understanding how they work may reveal the keys to ...