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NFL Week 18 picks straight up and against spread

NFL Week 18 picks straight up and against spread: Seahawks or 49ers for NFC's top seed?

The first weekend of calendar year 2026 also marks the final one of the 2025 NFL regular season − and the league seems poised to ring in the new year properly.

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Best NFL Picks and Predictions Today (How to Bet Texans vs. Chargers on Saturday in NFL Week 17)

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NFL DFS picks for Bucs-Panthers, 49ers-Seahawks: Top daily fantasy lineups for Week 18 Saturday

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Pro Picks: Panthers, Ravens Will Win Their Divisions. 49ers Will Edge Seahawks for NFC's No. 1 Seed

The NFL’s final weekend of the regular season features a winner-take-all game between the Ravens-Steelers and a battle for the NFC’s No. 1 seed between the Seahawks-49ers.

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Super Bowl odds: Rams, Seahawks are co-favorites ahead of Broncos, 49ers

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NFC West will be decided by 49ers' offense taking on Seahawks' smothering defense

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49ers bold predictions for huge Week 18 clash with Seahawks

Brock Purdy has transformed into an elite quarterback at the perfect time.

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Seahawks bold predictions for NFC West decider against 49ers

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Trent Williams' injury update is bad news for 49ers ahead of pivotal game vs. Seahawks

Best NFL Picks and Predictions Today for Week 17 (Bet on Eagles to Upset Bills in Buffalo)

It's time to grab a cup of coffee, find a spot on the couch, and place your bets for today's NFL action. If you're looking for some bets to tail, look no furthe

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NFL DFS picks, Bears vs. 49ers: Top daily Fantasy lineups, advice, stacks for 'Sunday Night Football'

DFS multimillionaire Mike McClure reveals his top daily Fantasy advice for the 'SNF' matchup of Bears vs. 49ers

Jaguars vs Colts Predictions, Picks & Best Bet for Today's NFL Week 17 Game

Our Jaguars vs. Colts predictions expect Jacksonville's offense to do whatever it wants on Sunday, December 28, 2025. Free NFL picks for Week 17.

SportsLine

NFL DFS, Week 17 2025: Top FanDuel, DraftKings picks, Saturday lineups from a daily Fantasy pro

The Week 17 NFL schedule continues on Saturday with two games and a player pool that features options such as Justin Herbert, C.J. Stroud, Nico