People with leukemia may have high levels of uric acid. If large numbers of cancer cells die rapidly, they release significant amounts of uric acid into the bloodstream, which the kidneys are ...

Researchers describe a novel acidic niche within lymph nodes that plays an integral role in regulating T cell activation. In the fight against cancer, the immune system is the first line of defense.

All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic ...

Leukocytosis and the Retinoic Acid Syndrome in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide. JCO 18 , 2620-2625 (2000). DOI: 10.1200/JCO.2000.18.13.2620 ...

All-trans retinoic acid (ATRA) and chemotherapy are curative in patients with non–high-risk acute promyelocytic leukemia (APL) (white-cell count <10,000 per cubic millimeter). However ...

A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows. Led by researchers ...

"The information revealed by our study tells us that the influence of this niche needs to be considered in approaches to rejuvenate old HSCs for treating aging-associated leukemia or immune ...

Dr. Bhatia and colleagues from UAB, University of Zurich, and Osaka University discovered that TKIs (drugs that most leukemia patients are treated with) do not eliminate disease-propagating leukemic ...