Nine newer antipsychotics, called atypical antipsychotics, are used as "augmentation therapy," or add-ons to treat depression that hasn't responded to antidepressants or other treatments.

The antipsychotic was begun at a dose of 7.5 mg daily to control atypical thinking and behavior. Acute mania developed within 2-3 weeks and gradually resolved with discontinuation of olanzapine.

Management of adverse events is a major concern of clinicians who use antipsychotic drugs. The incidence of motor side effects is dose dependent. Atypical antipsychotic drugs are less likely to ...