News

BMJ22h
AB0589 CANCER PREVALENCE IN SYSTEMIC LUPUS ERYTHEMATOSUS: A PORTUGUESE COHORT STUDY WITH 15 YEARS OF FOLLOW-UP
Background An increased risk of malignancy was reported in patients with Systemic Lupus Erythematosus (SLE) [1-3]. Objectives To estimate the prevalence of cancer in a Portuguese cohort of patients ...
BMJ5d
Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis
Objectives Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during ...
BMJ1d
Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017
Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...
BMJ3d
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator ...
Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological ...
BMJ10d
2023 ACR/EULAR antiphospholipid syndrome classification criteria
Objective To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of ...
BMJ13d
Understanding sex-related differences in healthcare utilisation among patients with inflammatory arthritis: a population-based study
Objectives Our aim was to compare patterns of musculoskeletal-related healthcare utilisation between male and female patients before and after the diagnosis of inflammatory arthritis (IA). Methods We ...
BMJ9mon
Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis
Objectives Rheumatoid arthritis (RA) is an autoimmune disease characterised by aggressive fibroblast-like synoviocytes (FLSs). Very few RA patients-derived FLSs (RA-FLSs)-specific surface signatures ...
BMJ6d
Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis
5 CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Faculté de Médecine, University of Paris City, Paris, France Objectives Alterations in tryptophan (Trp) metabolism have ...
BMJ13d
ASAS consensus definition of early axial spondyloarthritis
Objectives To develop a consensual definition for the term ‘early axial spondyloarthritis—axSpA’—and ‘early peripheral spondyloarthritis—pSpA’. Methods The ASAS (Assessment of SpondyloArthritis ...
BMJ6d
Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at ...
2 Clinical Development, Antares Pharma Inc, Ewing, New Jersey, USA 3 Medical Department, Antares Pharma Inc, Ewing, New Jersey, USA Objective To compare the relative bioavailability, safety and ...
BMJ8d
Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration
Correspondence to Professor Shiquan Sun, Xi'an Jiaotong University, Xi'an, Shaanxi, China; sqsunsph{at}xjtu.edu.cn; Professor Guangdun Peng, Chinese Academy of Sciences, Guangzhou, Guangdong, China; ...
BMJ13d
Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis
Correspondence to Dr Meredyth G Ll Wilkinson, Infection, Immunity and Inflammation Research and Teaching Department, UCL, London, WC1N1EH, UK; meredyth.wilkinson.14{at}ucl.ac.uk; Dr Elizabeth C Rosser ...