Objectives Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during ...

Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...

Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological ...

Objective To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of ...

5 CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Faculté de Médecine, University of Paris City, Paris, France Objectives Alterations in tryptophan (Trp) metabolism have ...

2 Clinical Development, Antares Pharma Inc, Ewing, New Jersey, USA 3 Medical Department, Antares Pharma Inc, Ewing, New Jersey, USA Objective To compare the relative bioavailability, safety and ...

Correspondence to Professor Shiquan Sun, Xi'an Jiaotong University, Xi'an, Shaanxi, China; sqsunsph{at}xjtu.edu.cn; Professor Guangdun Peng, Chinese Academy of Sciences, Guangzhou, Guangdong, China; ...

Background: Although clinical trials have shown that denosumab (Dmab) significantly increases bone mineral density at key skeletal sites more than zoledronic acid (ZA), evidence from randomized trials ...

Chimeric antigen receptors (CARs) are synthetic proteins designed to direct an immune response toward a specific target and have been used in immunotherapeutic applications through the adoptive ...

Background An increased risk of malignancy was reported in patients with Systemic Lupus Erythematosus (SLE) [1-3]. Objectives To estimate the prevalence of cancer in a Portuguese cohort of patients ...

Objectives To characterise the peripheral blood cell (PBC) gene expression changes ensuing from mycophenolate mofetil (MMF) or cyclophosphamide (CYC) treatment and to determine the predictive ...

Background It is known in the literature that exercise is effective on pain and function in the treatment of chronic low back pain (CLBP). However, it is emphasized that there is insufficient evidence ...