Tony McHale (pictured above) discovered he had an alteration in the BRCA2 gene at the age of 61, putting him at a much higher risk of developing prostate cancer. Shortly after, Tony joined the IMPACT ...

Cancer development is fundamentally an evolutionary process, however monitoring evolutionary dynamics through treatment remains challenging. Our team have recently developed a new methodology that can ...

Drug resistance is a major clinical challenge in cancer treatment, underlying both tumour recurrence and patient mortality (Vasan et al, 2019). Yet when cancer cells develop resistance to a drug, ...

Inactivation of mismatch repair (MMR) causes inherited and sporadic cancers 1. These tumours exhibit microsatellite instability (MSI) - length alterations within short repeats. MSI is a diagnostic and ...

Cancer research studies check whether new treatments are safe and work as intended. People who take part in these studies should be similar to those affected by the cancer, from different ethnicities ...

Metastatic cells are characterised as being highly invasive but weakly adhesive with rounded-amoeboid like features. These cells harbour high levels of cortical Myosin II activity and exert low ...

Paediatric-type diffuse high-grade glioma (PDHGG) is an umbrella term for a collection of related, but biologically and clinically distinct brain tumours primarily affecting children and young adults, ...

1 in 5 people with prostate cancer are diagnosed after their cancer has spread beyond the prostate, making the chance of cure low. Despite improvements in the treatment of advanced prostate cancer, ...

Prostate cancer (PCa) is a leading cause of male cancer-related death globally (1). The androgen receptor (AR) remains the main therapeutic target for lethal PCa, and although AR pathway inhibitors ...

The Wnt/β-catenin signalling pathway is a fundamental regulator of embryonic development, tissue homeostasis, and regeneration 1. Central to this pathway is the β-catenin destruction complex (DC), a ...

Image: Person walking towards the beach. Credits: Pixabay. Most people are aware of the benefits of exercise – it has been associated with improvements in overall health for some time. It makes sense ...

A spit test, where a sample can be collected at home, is more accurate at identifying future risk of prostate cancer for some men than the current standard PSA blood test, a new study reports. Results ...