In a mouse model, amyloid A accumulation, evidence of cell stress and expression of RAGE were closely linked. ... SAA1.1; and 60.3 ± 12.5 nM and B max = 2.7 ± 0.5 fmol/well, amyloid A.

Nanoparticles (NPs) are materials whose dimensions range from 1 to 1,000 nanometers (nm). Due to their nano-scale dimensions ...

The Inflation Reduction Act includes an exemption for orphan drugs for a single indication, but experts say this is far from ...

To reveal the science behind the protein–nanoparticle interaction and its implications for human health, a team of ...

Nanoparticles (NPs), materials with sizes ranging from 10 to 1,000 nm, are increasingly utilized as drug-delivery systems and ...

Researchers investigate the interaction dynamics of bovine serum albumin and silica nanoparticles using spectroscopy methods.

Elsie soon learned the cause - cardiac amyloidosis. "We used to think of it more as a rare disease," says Dr. Carly Fabrizio of Temple Health. But Dr. Fabrizio says heart failure specialists like ...

Cardiac amyloidosis has a wide spectrum of clinical manifestations but the most frequent presentation is heart failure. Differential diagnoses from other restrictive cardiomyopathies is important.

AstraZeneca has clearly made the rare disease transthyretin amyloidosis (ATTR) a key component of its rare disease pipeline, licensing a second drug candidate in the space of a couple of months.

Knocking out PERK in astrocytes reduces amyloid plaque burden in 5xFAD (top). The knockouts more quickly found the escape hole in the Barnes maze test (bottom). [Courtesy of Chen et al., Neuron, 2025.