Photobiomodulation (PBM), as a novel noninvasive therapy, has been extensively employed in neurodegenerative disorder research. However, its mechanism of action in Alzheimer's disease (AD) management ...

Given the 4.33-kDa molecular mass of Aβ40 and the 4.8-Å cross-β spacing, an Aβ40 fibril structure consisting of two cross-β subunits with the usual in-register, parallel β-sheet organization would ...

Justyna Dobrowolska Zakaria Northwestern University, Feinberg School of Medicine; Posted: 01 Jul 2024 This report provides exciting new insights into the potential physiological role of a proteolytic ...

Formation of amyloid-β (Aβ) fibrils is a central pathogenic feature of Alzheimer’s disease. Cell-secreted extracellular vesicles (EVs) have been suggested as disease modulators, although their exact ...

Myocardial infiltration by amyloid fibrils causes a severe and progressive form of heart failure. Until recently, this was not treatable. Several novel therapies have recently become available, ...

FIGURE 1.Morphology and sizes of aggregates formed after degradation of sfGFP amyloid fibrils. The electron micrographs of sfGFP aggregates (A) before and (B–E) after their treatment by (B) aBCry, (C) ...

99mTc-pyrophosphate imaging has been around for a long time. In the 1970s, it was used to image recent myocardial infarction. However, it has recently been recognized for its value in detecting ...

Radionuclide scintigraphy with technetium-labeled bisphosphonates has brought a paradigm shift in diagnosing cardiac amyloidosis (CA), with transthyretin CA now being effectively diagnosed without the ...

Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems. Diletta Ami 1 * Paolo Mereghetti 2 Antonino Natalello 1 * ... Under the optimal conditions ...

Hereditary transthyretin-mediated (hATTR) amyloidosis is an autosomal dominant disease caused by pathogenic variants in the transthyretin TTR gene, with most patients developing a mixed phenotype of ...

Alzheimer's disease (AD), the most common cause of dementia, is characterized by intracellular accumulation of neurofibrillary tangles and extracellular deposition of amyloid plaques, which are mainly ...