No neurofibrillary tangles or amyloid plaques were found in the parenchyma. Reactive gliosis, strong upregulation of microglia and multiple macrophages around the blood vessels in both white and ...

Nearly one million people worldwide are plagued annually by cutaneous leishmaniasis, a devastating skin infection caused by the Leishmania parasite. Predominantly affecting vulnerable populations ...

How do you discuss the risk-benefit profile of the amyloid-targeting therapies with patients and their caregivers, including adverse event considerations, adherence to treatment, travel to the ...

An early look at the phase 1b/2a data showed amyloid levels fell below a disease threshold in 81% of patients after 28 weeks. The Swiss drugmaker has identified the speed at which amyloid is ...

Histological examination shows amyloid-laden vessels and the appearance of Aβ in close association with inflammatory cells, implicating Aβ as the potential trigger for the inflammatory response.

Amyloid-Targeting Therapies in Alzheimer Disease: Mechanisms of Action, Efficacy, and Safety Considerations EP: 9 . Real-World Implications of Changes in CDR-SB Score in Patients Receiving Amyloid ...

Scientists at the University of Toronto studying the hermaphroditic worm Caenorhabditis elegans found that amyloid-like structures—proteins often associated with diseases like Alzheimer’s ...

Romano added that an ongoing proteomics analysis has picked up markers of cerebral amyloid angiopathy or ARIA, including MMP7 and MMP9. As previously reported, AL002 did not affect brain amyloid ...

Also, in February, Lilly withdrew an application that asked CHMP to approve its amyloid tracer florbetapir for monitoring a person’s response to amyloid immunotherapy. The committee said additional ...

which is developing ALN-APP in collaboration with Regeneron for both Alzheimer’s and related condition cerebral amyloid angiopathy (CAA), which can cause haemorrhaging in the brain. Eisai and ...