Carnegie Mellon University neuroscientists have discovered connections between the globus pallidus and a rarely explored area of the brain.

Demonstrated target engagement of ATH434 The 50 mg dose reduced iron accumulation in the substantia nigra, putamen, and globus pallidus The reduced accumulation ... A second Phase 2 open-label 2 ...

Demonstrated target engagement of ATH434 The 50 mg dose reduced iron accumulation in the substantia nigra, putamen, and globus pallidus The ... A second Phase 2 open-label 2 Biomarker trial ...

HighlightsTopline data for ATH434-201 randomized, double-blind Phase 2 clinical trial on track for expected release by early February ...

During the open-label study period ... desynchronization of abnormal neuronal firing patterns of internal globus pallidus and substantia nigra pars reticulata neurons as mentioned above.

We report microelectrode data from the globus pallidus interna (GPi) and globus pallidus externa (GPe) in children undergoing deep brain stimulation (DBS) for dystonia and investigate whether GPi and ...

All patients had permanent electrodes placed bilaterally in PPN and globus pallidus internus (GPi). A Likert scale on quality of life was also obtained from the patient/parents as applicable. Results: ...

Background Deep brain stimulation (DBS) of the globus pallidus interna (GPi) is a highly efficacious treatment for cervical dystonia, but its mechanism of action is not fully understood. Here, we ...