In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.

In regenerative science, B7-33's potential to influence fibroblast activity and collagen turnover suggests possible implications for tissue repair and wound healing. Given that fibrosis is often a ...

A new study published in The New England Journal of Medicine showed that for high-risk patients with pulmonary arterial ...

In PAH, these remodeling processes within these arterioles ... exercise tolerance and pulmonary vascular resistance. Due to this superiority, the study was terminated prematurely—a continuation ...

In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases.

Their roles in cardiovascular health are particularly significant as they engage in processes like inflammation, apoptosis, vascular remodeling, and cardiac hypertrophy. For example, tsRNAs ...

In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases.

Among high-risk adults with pulmonary arterial hypertension ... activin signaling inhibitor that targets the underlying vascular remodeling in PAH. In the ZENITH trial, 172 patients with World ...

"We know that during the remodeling process fibroblasts are activated," said Cheng Hong, MD, Ph.D., pulmonary vascular medicine specialist at the First Affiliated Hospital of Guangzhou Medical ...

This multi-target approach aims to mitigate the inflammatory and proliferative pathways that contribute to pulmonary vascular remodeling associated with PAH. Currently, the drug is in the Phase ...