A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose ...

TRPC3 is predominantly expressed in fibroblasts and fibrosis-related pathways are upregulated in cystitis rats. The increased fibrosis markers and collagen fiber deposition are both reversed by TRPC3 ...

We found that an intact TGF-β signaling pathway in pre-neoplastic prostate cells suppresses survivin expression by activating retinoblastoma protein (Rb) and related pocket proteins via a ...

In MASLD and MASH, TGF-β signaling contributes to hepatocyte lipid accumulation, cell death and fibrosis progression through both Smad and non-Smad pathways. In HCC, TGF-β and other TGF-β-SF cytokines ...

Wnt pathway activation mutations (adenomatous polyposis coli, SMAD family member 4 ... alterations and suitable for putative Wnt pathway-targeted therapies (β-catenin/TGF-β inhibitors). The second ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...