Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase ...

A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to ...

RNA sequencing was performed to elucidate underlying signaling pathways, and pharmacological inhibition of the transforming growth factor‐beta pathway was assessed for its therapeutic potential.

Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University) of State Ethnic Affairs Commission, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China Key ...

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China (W.L., J.H., Y.D., J.W., Y.C.).

TRPC3 is predominantly expressed in fibroblasts and fibrosis-related pathways are upregulated in cystitis rats. The increased fibrosis markers and collagen fiber deposition are both reversed by TRPC3 ...

In MASLD and MASH, TGF-β signaling contributes to hepatocyte lipid accumulation, cell death and fibrosis progression through both Smad and non-Smad pathways. In HCC, TGF-β and other TGF-β-SF cytokines ...