Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

BELMONT, CA, USA I June 24, 2025 I Supercede Therapeutics, Inc., a startup biotech company focused on small molecule drug development, today announced ...

“Our latest discovery significantly enhances our understanding of the TGFB gene complex in PDAC, particularly in immunologically cold tumors,” said Dr. Sanjive Qazi, lead author.

Isobaric labeling has become a widespread tool for quantitative proteomic studies. Here, we report the development and evaluation of several dimethylated amino acids as novel isobaric tags for ...

Next, experts said, discussions will focus on other decisions, such as when and whether to prescribe the SGLT2 inhibitors with GLP-1 receptor agonists for the best outcomes. The Path From Glucose ...

The widely used class of drugs, called SGLT2 inhibitors and sold under brand names such as Jardiance and Farxiga, have been on the market for over a decade as Type 2 diabetes medications.

Transforming growth factor-β (TGF-β) signaling pathway plays an important role in tumorigenesis. Inhibition of the TGF-β type I receptor kinase is considered an attractive strategy for the treatment ...

Among the cohort, 16,417 patients were treated with JAK inhibitors, 35,373 were treated with TNF inhibitors and 21,218 were treated with biologic DMARDs with other modes of action.

Clinical practice over the timing of drug treatments for a type of heart failure called heart failure with a reduced ejection fraction (HFrEF) is changing. The four main types of treatment: ...