The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

In the meantime, the 49ers claimed ex-New York Jets running back Israel Abanikanda on Tuesday, according to Schefter. "49ers ...

SANTA CLARA, Calif. — San Francisco 49ers running back Christian McCaffrey likely suffered a partial tear of his posterior ...

Slow motion video shows where 49ers running back Christian McCaffrey seemingly injured himself and ended his season.

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

Just when it seemed that San Francisco 49ers running back Christian McCaffrey was starting to find his rhythm, in a moment of ...

After burying the San Francisco 49ers in a snow game Sunday, in which running back Christian McCaffrey left with a ...