Cancer research studies check whether new treatments are safe and work as intended. People who take part in these studies should be similar to those affected by the cancer, from different ethnicities ...

Drug resistance is a major clinical challenge in cancer treatment, underlying both tumour recurrence and patient mortality (Vasan et al, 2019). Yet when cancer cells develop resistance to a drug, ...

Proteolysis-targeting chimeras (PROTACs), particularly those incorporating the von Hippel–Lindau (VHL) E3 ligase ligand, present significant physicochemical challenges due to their large molecular ...

Metastatic cells are characterised as being highly invasive but weakly adhesive with rounded-amoeboid like features. These cells harbour high levels of cortical Myosin II activity and exert low ...

1 in 5 people with prostate cancer are diagnosed after their cancer has spread beyond the prostate, making the chance of cure low. Despite improvements in the treatment of advanced prostate cancer, ...

In a major step forward for cancer drug discovery, researchers have demonstrated how computational simulations can unravel the complex role of water molecules in drug ...

Our clinical PhD fellowships are provided to develop and support future leaders in clinical cancer research. The Clinical Academic Training Programme, ICR-Imperial is a programme which will provide ...