Can the Colts get their spark back in the run game this week? The stage is set for a big Jonathan Taylor workload, can he deliver?

Jonathan Taylor and the Indianapolis Colts came up short on Monday night, suffering defeat against a red-hot San Francisco 49ers side. The Colts put up a respectable fight, but they just couldn’t compete with the Niners, who have now stacked up five straight victories.

Both Indianapolis Colts star running back Jonathan Taylor and head coach Shane Steichen feel Philip Rivers has provided their team with "juice" by coming out of retirement to join them for the last four games of the 2025 NFL season.

Nelson is also the second offensive lineman in NFL history to be named to the Pro Bowl in his first eight seasons, joining legendary Cleveland left tackle Joe Thomas and putting himself on a track to earn a Hall of Fame nod at some point down the line.

San Francisco 49ers quarterback Brock Purdy completes a 17-yard pass to wide receiver Jauan Jennings. San Francisco 49ers running back Christian McCaffery bolts out of the backfield for a 24-yard gain.

Offense Will Look To Run Through NFL Leading Rusher Jonathan Taylor

These players have questions surrounding their teams and their roles in 2026. They may trend lower towards the 2026 Fantasy Football season.

NFL Network analyst Brian Baldinger breaks down the Indianapolis Colts offense when running back Jonathan Taylor is used under center.