Amyloid-Targeting Therapies in Alzheimer Disease: Mechanisms of Action, Efficacy, and Safety Considerations EP: 9 . Real-World Implications of Changes in CDR-SB Score in Patients Receiving Amyloid ...

Department of Neuroscience, Developmental, and Regenerative Biology, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, Texas 78249, United States ...

Scientists at the University of Toronto studying the hermaphroditic worm Caenorhabditis elegans found that amyloid-like structures—proteins often associated with diseases like Alzheimer’s ...

and cerebral amyloid angiopathy independent of APOE after adjusting for age, sex, cholesterol-lowering medication use, body mass index, smoking and education at false discovery rate (FDR) p-value ...

CD47 is found to play a pivotal role in this immunosuppression by inducing the production of amyloid-β (Aβ), which interacts with CD74 on B cells, leading to B-cell suppression and subsequent adaptive ...

Mivelsiran that is in phase II clinical trial for cerebral amyloid angiopathy, and phase I clinical trial for Alzheimer’s disease; and ALN-HTT02 that is in phase I clinical trial for Huntington’s ...

An early look at the phase 1b/2a data showed amyloid levels fell below a disease threshold in 81% of patients after 28 weeks. The Swiss drugmaker has identified the speed at which amyloid is ...

Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new ...

Unlike the FAVOR III Europe trial, 5 which used angiography-derived FFR solely as a traffic light to decide whether to treat a lesion and did not achieve comparable clinical results with the gold ...

Also, in February, Lilly withdrew an application that asked CHMP to approve its amyloid tracer florbetapir for monitoring a person’s response to amyloid immunotherapy. The committee said additional ...

Gerstmann-Sträussler-Scheinker disease and prion protein cerebral amyloid angiopathy add two more diseases to this branch. They are caused by different mutations in the prion protein gene and lead to ...