Single and multi-dose studies of the small molecule TREM2 agonist VG-3927 clear early safety hurdle. Meanwhile, new findings ...

Histological examination shows amyloid-laden vessels and the appearance ... A possible explanation could be that corticosteroids merely reduce cerebral vasogenic edema. However, in vitro research ...

Hypertension and advanced age are risk factors for arteriosclerotic cerebral small vessel disease (cSVD), a common cause of vascular dementia in elderly individuals. Circulating IGF-1 (insulin-like ...

A clinical diagnosis of cognitive status is rendered annually ... Braak staging and CERAD score), cerebral microinfarct, cerebral macroinfarct, cerebral amyloid angiopathy (CAA), cerebral ...

Her research project will include investigating mechanisms of cerebral amyloid angiopathy (CAA), caused when abnormal proteins build up in blood vessels in the brain, often leading to a bleeding ...

At the AD/PD 2025 International Conference on Alzheimer’s and Parkinson’s Diseases (AD/OD), during the ‘Abeta Targeting Therapies in AD’ symposium on 3 April, Roche presented interim trial data for ...

data from 2 cohorts (DiViNAS [Disease Variability in NOTCH3-Associated SVD] and VASCAMY [Vascular and Amyloid Predictors of Neurodegeneration and Cognitive Decline in Nondemented Subjects]) consisting ...

Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new ...

Collinge’s group had previously reported that some of the growth hormone batches that four members of the group received had been contaminated with amyloid beta and tau, two proteins that are ...

AD-associated pathologies like cerebral amyloid angiopathy (CAA) are also affiliated with cognitive ... leading to new possibilities for the prediction, diagnosis, and mitigation of this debilitating ...