Parkinson’s disease is often mistaken for routine aging—but ignoring early warning signs can delay crucial treatment. For ...

A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

Findings from a pilot trial show that deep brain stimulation (DBS) of the nucleus accumbens (NAc ... and plays a critical role in integrating dopaminergic reinforcement signals.

mCD8::mCherry was used to demarcate nucleus and cytoplasm (white dotted circles). (D-E) Quantification of nucleus localization index (NLI) of PAM-α1 and DPM neurons under un-starved, un-trained and ...

Dopaminergic deficiency, a hallmark of PD, disrupts sexual function by impairing dopamine’s role in libido, arousal, and orgasm regulation. While reduced dopamine levels can cause hyposexuality, ...

Researchers from the Champalimaud Foundation have shed light on the puzzling relationship between dopamine and rest tremor in Parkinson's disease, finding that preserved dopamine in certain brain ...

We aimed to evaluate microscale changes in the bilateral red nucleus and substantia nigra of patients with ... neurodegenerative disease caused by the degeneration of nigrostriatal dopaminergic ...

Midbrain dopaminergic (DAergic) neurons play a major regulatory role in in goal-directed behavior and reinforcement learning. DAergic neuron activity, and therefore spatiotemporal properties of ...