The team suspects that neurogenesis happens in other parts of the adult brain, too. In mice, new neurons are regularly made ...

A chimeric protein consisting of a cell-adhesive peptide derived from a neural cell adhesion molecule and a collagen-binding domain was synthesized using recombinant DNA technology. Here, we ...

Methods and results: We performed a signal sequence trap in combination with a functional cloning method and identified neural cell adhesion molecule (NCAM, CD56) as a candidate. We examined the NCAM ...

SAN FRANCISCO, Sept. 10, 2024 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for disorders of the nervous system, today ...

Cell adhesion is the primary phenomenon behind cell-cell and cell-environment interactions which are of utmost importance during both ontogenesis and phylogenesis of neural tissue. Significantly, in ...

The molecular mechanism of homophilic adhesion between neural cell adhesion molecules (NCAM) was investigated by direct force measurements. The force-distance profiles demonstrated that multiple ...

Upregulated transcripts in GLC19, as assessed by microarray analysis, comprised proteins involved in regulation of cellular growth (NGFRAP1/BEX3), adhesion, glutathione metabolism and, in particular, ...

During cell adhesion, the extracellular domain binds to another cell adhesion molecule. In response, the transmembrane region rearranges the structure of the intracellular domain—a process ...

The Down syndrome cell adhesion molecule (DSCAM) is broadly expressed in the nervous system and functions in neural development and network formation by mediating homophilic adhesion between cells.

Cell migration and axonal pathfinding are crucial aspects of neural development. Neurons are born in proliferative zones from where they migrate to their final destination. After arrival, they send ...