Right ventricular hypertrophy, right ventricular systolic pressure, and vascular remodeling—all complications of pulmonary hypertension—were reduced as compared with controls that did not ...

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease that pathologically increases pulmonary vascular resistance. Ultimately, this leads to right ventricular failure and ...

Serotonin can promote both pulmonary vasoconstriction and pulmonary vascular remodeling and is thought to be involved in the pathobiology of PAH. A polymorphism in the serotonin transporter (SERT ...

In PAH, these remodeling processes within these arterioles ... exercise tolerance and pulmonary vascular resistance. Due to this superiority, the study was terminated prematurely—a continuation ...

"We know that during the remodeling process fibroblasts are activated," said Cheng Hong, MD, Ph.D., pulmonary vascular medicine specialist at the First Affiliated Hospital of Guangzhou Medical ...

cholesterol the role of natriuretic peptide signaling and mineralocorticoid receptor antagonism in protecting against adverse remodeling in the pressure-overloaded heart the molecular pathogenesis of ...

cholesterol the role of natriuretic peptide signaling and mineralocorticoid receptor antagonism in protecting against adverse remodeling in the pressure-overloaded heart the molecular pathogenesis of ...

Inhibikase (IKT) pivots to IkT-001Pro for PAH amid competition like Merck’s sotatercept. Backed by $97.5M, results will ...

In regenerative science, B7-33's potential to influence fibroblast activity and collagen turnover suggests possible implications for tissue repair and wound healing. Given that fibrosis is often a ...

Over time, the small pulmonary arteries thicken and become blocked due to a progressive accumulation of cells in the vascular wall. Sotatercept works as an “activin receptor ligand trap” and ...