By simultaneously engaging two distinct antigens or pathways, bsAbs disrupt multiple signaling cascades simultaneously ... Instead, dual immune checkpoint inhibitors (CPIs) enhance immune activation ...

Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University) of State Ethnic Affairs Commission, College of Pharmacy, Yanbian University, Yanji, Jilin Province 133002, China Key ...

Nat Rev Clin Oncol 18: 345-362. 11. Wu Q, Jiang L, Li SC, et al. (2021): Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42: 1-9. 12. Bai H, Wang Z, Li M, et ...

This study sought to determine whether the SOCS3/JAK/STAT3 signaling pathway, which controls macrophage polarization, contributes to the cardiotoxicity caused by PD-1/PD-L1 inhibitors. The PD-1/PD-L1 ...

Janus kinase (JAK) inhibitors were associated with more infections, particularly herpes infections, in patients with atopic dermatitis (AD) compared with biologics, in a cohort study. A ...

The presentation highlighted tolebrutinib’s potential as the first Bruton’s tyrosine kinase (BTK) inhibitor to receive regulatory approval for the treatment of progressive MS. During the Clinical ...

Observational studies and small randomized controlled trials have suggested the benefits of early introduction of sodium–glucose cotransporter 2 inhibitors (SGLT2is) in acute heart failure (AHF).

SGLT2 inhibitors significantly improve hemoglobin and hematocrit levels in CKD patients, enhancing anemia management. The KDIGO 2024 guideline endorses SGLT2 inhibitors for CKD patients ...

Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China State Key Laboratory of ...

The Department of Government Efficiency, which is led by Elon Musk, arrived Friday at U.S. Peace Corps headquarters in Washington, D.C., suggesting it could be the latest target of the Trump ...

Survivin Suppression by TGF-β Signaling: Survivin, an inhibitor of apoptosis protein (IAP), is strongly ... and related pocket proteins via a Smad-dependent mechanism. These proteins then interact ...