Subsequently, the cells were exposed to TGF-β stimulation for 24 h ... puromycin selection at a concentration of 6 μg/mL (Beyotime, Shanghai, China). WB and IP experiments were conducted as previously ...

Western blot (WB) and Mass Spectrometry (MS ... Based on the fundamental biological pathways of micropeptides, they can be roughly categorized into the following types (Table 1). These micropeptides ...

Multi-modal data integration of single-nuclei RNA and ATAC sequencing with spatial transcriptomics, provides new molecular insights into gene regulatory networks driving cell state transitions in ...

For instance, the team discovered that non-cancerous cells bordering cancer cells were in a unique state driven by transforming growth factor-beta (TGF-β) signaling, a critical pathway involved ...

Animal experiments were used to analyze the effect of VIRMA on the tumorigenic ability of A549. The activity of the TGF-β signaling pathway was evaluated by Western blotting. VIRMA is overexpressed in ...

RNA sequencing was performed to elucidate underlying signaling pathways, and pharmacological inhibition of the transforming growth factor‐beta pathway was assessed for its therapeutic potential.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...