A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose ...

TRPC3 is predominantly expressed in fibroblasts and fibrosis-related pathways are upregulated in cystitis rats. The increased fibrosis markers and collagen fiber deposition are both reversed by TRPC3 ...

In MASLD and MASH, TGF-β signaling contributes to hepatocyte lipid accumulation, cell death and fibrosis progression through both Smad and non-Smad pathways. In HCC, TGF-β and other TGF-β-SF cytokines ...

Wnt pathway activation mutations (adenomatous polyposis coli, SMAD family member 4 ... alterations and suitable for putative Wnt pathway-targeted therapies (β-catenin/TGF-β inhibitors). The second ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Pathogenic variants in several signaling pathways related to skeletal growth plate homeostasis, including transforming growth factor-β (TGFβ)-bone morphometric protein (BMP) pathway, atrial ...