By synthesizing current insights on both RTK and non-RTK mediated resistance against anti-EGFR therapies, this review aims to ...

TGF-β1 has been shown to influence cell cycle progression through many mechanisms including activation of the cyclin-dependent kinase inhibitors p21 Cip (ref. 41), p27 Kip (ref. 42, 43) and p15 ...

A panelist explains how the distinct mechanisms of erythropoiesis-stimulating agents (ESAs), luspatercept, and imetelstat ...

Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor with anti-microbial properties found in mucosal fluids. It is expressed during cutaneous wound healing. Impaired ...

Pliant Therapeutics has terminated its idiopathic pulmonary fibrosis (IPF) program after digging into the increased rate of ...

Anita Turk, MD, discusses the unmet needs that still exist in the realm of colorectal cancer treatment and management.

Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

CD8⁺ T cells are the immune system's frontline warriors, charged with detecting and eliminating cancer cells. But in the ...

SOUTH SAN FRANCISCO, Calif., June 27, 2025 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX) today announced that ...

Medulloblastoma the most common malignant pediatric brain tumor with a high risk of metastasis and poor survival outcomes. To delineate the ...

IL-8), tumor necrosis factor (TNF), transforming growth factor (TGF), and CXC chemokines (CXCL1, CXCL9, CXCL10, CXCL11, CXCL12). These factors contribute to tumor growth, metastasis, and immune ...

CD8⁺ T cells are the immune system's frontline warriors, charged with detecting and eliminating cancer cells. But in the hostile and chronic environment of tumors, these cells often falter. Prolonged ...