Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

SANTA CLARA, Calif. — San Francisco 49ers running back Christian McCaffrey likely suffered a partial tear of his posterior ...

The San Francisco 49ers shored up their suddenly thin running back corps on Tuesday by claiming Israel Abanikanda off waivers from the New York Jets.

The San Francisco 49ers on Tuesday announced how they’d replace running back Christian McCaffrey. In a slew of roster moves ...

The San Francisco 49ers claimed running back Israel Abanikanda off waivers from the New York Jets on Tuesday, one day after ...

RB Christian McCaffrey suffers potentially season-ending knee injury in loss to Bills, adding to team's struggles.

Rookie Isaac Guerendo steps up as 49ers seek to fill void left by McCaffrey and injured backup Jordan Mason. Coach Shanahan ...

After missing the first eight games with an Achilles injury to begin the season, running back Christian McCaffrey will be ...

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

The dark and gloomy 2024 season gets worse for the San Francisco 49ers. On Monday, Kyle Shanahan delivered the worst-case ...

It’s been a rough day – and a rough season - for 49ers fans. Many are depressed over a brutal loss Monday night in Buffalo ...