San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Pofcast; ...

Christian McCaffrey was viewed as the savior for the San Francisco 49ers. His return was supposed to cure all of the ...

The Buffalo Bills can clinch their fifth straight AFC East title with a win over the San Francisco 49ers on Sunday night. To ...

Cook may not emulate those numbers but he should be in for a great game. Stock down: 49ers running back Christian McCaffrey ...

Running back Christian McCaffrey says the 49ers are “hungry” to make a playoff push even with the defending NFC champions ...

Three things I’m pondering as the Bills return from their bye for the stretch run… Mila-No More Waiting Matt Milano is ...

Several star running backs received a ratings bump in Madden NFL 25 this week, including Philadelphia Eagles running back ...

Yet on Sunday night in frigid Orchard Park, the 49ers, mired at 5-6 and a game out of first place in the NFC West, find their ...

Josh Allen is currently the frontrunner in NFL MVP odds, and we expect the Bills superstar quarterback to use his athleticism ...

Christian McCaffrey and Deebo Samuel are guys that can hurt you in a plethora of ways. Tight end George Kittle is perhaps the ...

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...