The clinical presentations of early idiopathic Parkinson disease (IPD) substantially overlap with those of atypical parkinsonian syndromes such as multiple system atrophy (MSA) and progressive ...

Myocardial fibrosis is a major contributor to the development and progression of heart failure. Significant progress in the understanding of its pathobiology has led to the introduction and ...

This investigation examined the factors involved in predicting the responses of micrometastases to targeted 225Ac-based therapies and in optimizing these therapies through the use of cocktails of ...

PET is a powerful molecular imaging technique that can provide functional information on living objects. However, the spatial resolution of PET imaging has been limited to around 1 mm, which makes it ...

PSMA PET Imaging Protocols and Reporting. The recommended imaging protocols for 68 Ga-PSMA-11 and 18 F-DCFPyL are similar. In short, the administered activity, based on the prescribing information, is ...

Prostate-specific membrane antigen (PSMA)–targeting radiopharmaceuticals, such as the novel [177Lu]Lu-HTK03170, present a promising therapeutic option for metastatic castration-resistant prostate ...

RESULTS. Of the 126 patients analyzed, 14 (11%) had SARs ().Baseline complete blood count, demographics, and treatment history were analyzed with a univariable logistic regression model ().Age, prior ...

Antiamyloid therapies for Alzheimer disease recently entered clinical practice, making imaging biomarkers for Alzheimer disease even more relevant to guiding patient management. Amyloid and tau PET ...

Digital PET/CT systems with a long axial field of view have become available and are emerging as the current state of the art. These new camera systems provide wider anatomic coverage, leading to ...

Granzyme B. Granzyme B, a serine protease that induces apoptosis in target cells, is released by activated CD8-positive T cells and natural killer cells, in addition to some immunosuppressive cells () ...

The aim of this study was to validate a previously developed deep learning model in 5 independent clinical trials. The predictive performance of this model was compared with the international ...

Current protocols necessitate imaging 2 18F-labeled tracers in separate sessions. Herein, we report on the development and testing of a protocol that sequentially images 2 18F-labeled tracers—18F-(2 S ...