Alkenes can be dihydroxylated by two different stereochemical pathways: anti-dihydroxylation or syn-dihydroxylation. The opening of epoxides follows the anti-dihydroxylation mechanism, …

Jul 1, 2011 · The mechanism of alkene dihydroxylation is a concerted cycloaddition reaction where the C-C pi bond combines with two Os=O bonds to give a five-membered ring structure …

Oct 22, 2025 · KMnO4 and OsO4 are used for syn dihydroxylation of alkenes. In this article, we will discuss the mechanism of syn dihydroxylation followed by some practice.

Dihydroxylation is the process by which an alkene is converted into a vicinal diol. Although there are many routes to accomplish this oxidation, the most common and direct processes use a …

The Upjohn Dihydroxylation allows the syn -selective preparation of 1,2-diols from alkenes by the use of osmium tetroxide as a catalyst and a stoichiometric amount of an oxidant such as NMO …

Dihydroxylation is an oxidation process when an alkene is converted into a vicinal diol, also known as 1,2-diols or glycols. The most frequent and direct process of dihydroxylation is using a …

With oxidative cleavage, the carbon-carbon bond of an alkene is completely broken, and in many cases this will break the molecule into two pieces. Alkenes can be cleaved by oxidation with …

The dihydroxylation of an alkene consists of adding an -OH group to each carbon to form vicinal diols. This reaction can be carried out with osmium tetroxide in hydrogen peroxide, or with …

Enantioselective dihydroxylation of α -methylstyrene 12 was achieved with 68% ee (S), whereas other alkenes were oxidized with lower selectivities. This early study once again highlights the …

Barry Sharpless was the first to develop a general, reliable enantioselective alkene dihydroxylation, referred to as the Sharpless asymmetric dihydroxylation (SAD).