It is a cell-surface receptor that recognizes apolipoprotein B100 (ApoB100), which is embedded in the outer phospholipid layer of very low-density lipoprotein (VLDL), their remnants—i.e. intermediate …

Cells readily utilize cholesterol by internalizing lipoprotein ligands containing chylomicron, low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), or very low-density lipoprotein (VLDL) …

Apr 10, 2025 · Clearance of circulating plasma LDL (low-density lipoprotein) cholesterol by the liver requires hepatic LDLR (low-density lipoprotein receptor). Complete absence of functional LDLR …

Jul 23, 2025 · The Low-Density Lipoprotein (LDL) receptor is a protein found on the surface of cells, particularly liver cells. It functions like a gatekeeper or a docking station.

The presence of the low-density lipoprotein (LDL) receptor on the surface of cells is essential in maintenance of extracellular and membrane cholesterol homeostasis.

Here we focus on how cells take up LDL in a regulated process mediated by the LDL receptor (LDLR). Patients with a homozygous mutation in LDLR can display more than five-fold higher LDL levels and …

The LDLR gene provides instructions for making a protein called the low-density lipoprotein receptor. This receptor binds to particles called low-density lipoproteins (LDLs), which are the primary carriers …

May 12, 2021 · In this review, we focus on the discovery, structure, and normal function of the LDL receptor, as well as its role in a selection of infections. The LDL receptor plays an important role in …

Apr 1, 2009 · Abstract In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways …

Sep 15, 2024 · Maintaining tight regulation of cholesterol homeostasis is therefore essential, elegantly highlighted by the control of hepatic low-density lipoprotein receptor (LDLR) abundance and …