Neural stem cells (NSCs) are pluripotent stem cells that only exist in the central nervous system. They have good self-renewal potential and ability to differentiate into neurons, astrocytes, and oligodendrocytes and improve the cellular microenvironment.

Stem cell-based therapies have emerged as a promising approach for treating various neurological disorders by harnessing the regenerative potential of stem cells to restore damaged neural tissue and circuitry.

Jul 1, 2023 · Neural stem cells (NSCs) play a unique role in the treatment of neurological diseases for their abilities to self-renew and form different neural lineage cells, such as neurons and glial cells.

There are several sources of neural stem cells such as human embryonic stem cells, human fetal brain-derived neural stem/progenitor cells, human induced pluripotent stem cells, direct reprogrammed astrocytes. Stem cell sciences are a promising …

Oct 12, 2017 · Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on NSC transplantation is a promising tool for the treatment of nervous system diseases. However,...

Oct 15, 2024 · Cell therapy for stroke has largely focused on human fetal brain-derived neural stem cells that can differentiate into neurons and astrocytes to provide neuronal replacement and release...

Oct 1, 2018 · Two classes of neural stem cells (NSCs) can be distinguished, notably embryonic stem cells (pluripotent, which create cells from each of the three embryonic germ layers) and adult stem cells (multipotent, which can create lineage-specific cell types).

Sep 26, 2021 · Neural stem cells (NSCs) are pluripotent stem cells that only exist in the central nervous system. They have good self-renewal potential and ability to differentiate into neurons, astrocytes, and oligodendrocytes and improve the cellular microenvironment.

Mar 6, 2024 · NSCs have the potential of self-renewal and differentiation, which shows great foreground as the replacement therapy of endogenous cells in neurological diseases, which broadens a new way of cell therapy.

Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on NSC transplantation is a promising tool for the treatment of nervous system diseases. However, there are still many issues and controversies associated with ...

Apr 20, 2023 · This review examines how the ability to generate diverse CNS cell types from stem cells, along with a deeper understanding of cell-type-specific functions and pathology, is advancing preclinical development of cell products for …

1 day ago · The reported findings, published today in Cell Stem Cell, will certainly be of deep interest to scientists studying a range of adult neurological diseases and aging. In the neural landscape, rousing NSCs from dormancy, where they conserve resources and energy, is key for neural regeneration and brain injury repair.

Jul 25, 2024 · Stem cell-based therapies have emerged as a promising approach for treating various neurological disorders by harnessing the regenerative potential of stem cells to restore damaged neural tissue and circuitry.

Effective strategies must be developed to isolate, enrich and propagate homogeneous populations of neural stem cells, and to identify the molecules and mechanisms that are required for their...

Dec 17, 2024 · Neural stem cell transplantation is an emerging treatment for various neurological disorders and injuries that works by implanting human-derived stem cells into damaged or diseased areas of...

Mouse neural stem cells (E) or human embryonic stem cell–derived neural precursor cells (F) integrate into inflamed brains. Inflammation-induced axonal injury in untreated experimental mice with autoimmune encephalomyelitis (G) is reduced …

Feb 4, 2025 · Stem cell therapies have in many respects revolutionized the way we explore and treat neurological diseases. Characterizing past and ongoing clinical trials using stem cells for neurological diseases will provide important insights for academia, industry and government. Based on the Trialtrove database, we retrospectively analyzed 530 clinical trials initiated by …

Global landscape of stem cell therapy trials for neurological diseases. a: Stem cell therapy trials, by status, as of December 31, 2023.b: The number of clinical trials worldwide from 1998 to 2023, divided into five-year periods, with a standalone analysis for 2023.Each period includes the total number of trials and a breakdown by phase.

Dec 18, 2024 · Neural stem cells (NSCs) have increasingly been recognized as the most promising candidates for cell-based therapies for the central nervous system (CNS) injuries, primarily due to their pluripotent differentiation capabilities, as well as their remarkable secretory and homing properties.

Stem cells afford the plasticity to generate, repair, and change nervous system function. Combined with reprogramming technology, human somatic cell-derived NSCs and their progeny can model neurological diseases with improved accuracy.

Neural stem cells (NSCs) have demonstrated multimodal therapeutic function for stroke, which is the leading cause of long‐term disability and the second leading cause of death worldwide.

Challenges of neural stem cell-based therapy in Alzheimer’s disease. The source, adequate differentiation, isolation, cell dose, delivery region, time frame, immune rejection, and location of transplantation are all challenges requiring further study.

Apr 21, 2023 · Transplantation of human neural stem cells (hNSCs) is a promising regenerative therapy to promote remyelination in patients with multiple sclerosis (MS). Transplantation of hNSCs has been shown to increase the number of CD4 + CD25 + Foxp3 + T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong ...

Feb 3, 2025 · Generation of neural stem cell lines from fetuses carried by mice exposed to MIA treatment. Neural stem cells (NSCs) were obtained from fetuses at E12.5 to establish adherent proliferative cell lines.

Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site, orchestrate the differentiation process, and promote the integration of …