158K views · 361 reactions | 3 Cardiac Meds To Know 變DIGOXIN Class:...

The Digitalis Dilemma - Mastering Digoxin! Digoxin is a potent cardiac glycoside that can be a game-changer in specific situations, but also carries significant risks. Let's recap its key actions and how to handle its toxicity! Digoxin's Dual Power: ➕ Positive Inotropy: It strengthens heart muscle contractions, boosting cardiac output – vital in heart failure. ➖ Negative Chronotropy: It slows down the heart rate and decreases AV nodal conduction, making it excellent for controlling ventricular r

The "Stone Heart" Theory in Digoxin Toxicity: A Modern Perspective Stone Heart Syndrome refers to a theoretical, lethal state of sustained myocardial contraction (systolic contracture) due to profound intracellular calcium overload. In digoxin toxicity, this was hypothesized to occur when IV calcium administration exacerbates the digoxin-induced inhibition of the Na /K -ATPase pump, which already causes elevated cytosolic calcium. The result is a non-relaxing, "stone-like" heart incapable of fil